Responses in HER-2 Transgenic Mice Protective and Therapeutic Antitumor Potent Th Cell Epitopes Induce Distinct HER-2 DNA and Protein Vaccines Containing
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منابع مشابه
HER-2 DNA and protein vaccines containing potent Th cell epitopes induce distinct protective and therapeutic antitumor responses in HER-2 transgenic mice.
Overexpression of the growth factor receptor HER-2 (c-erbB-2, neu) has transforming potential and occurs in approximately 20-30% of breast and ovarian cancers. HER-2 is a self Ag, but Abs and T cells specific for HER-2 have been isolated from cancer patients, suggesting HER-2 may be a good target for active immunotherapy. We constructed rat HER-2 DNA and protein vaccines containing potent Th ce...
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تاریخ انتشار 2003